Phenospace

A new phenotypic screening platform for worm behaviour quantification

We have built a new system for high resolution, high throughput worm behaviour quantification. It sets a new standard for phenotypic screening in C. elegans and is enabling new kinds of screens to discover neuroactive molecules and repurpose drugs to treat rare genetic diseases.

This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 714853)

Publications

I Barlow, L Feriani, E Minga, A McDermott-Rouse, T O’Brien, Z Liu, M Hofbauer, JR Stowers, EC Andersen, SS Ding, AEX Brown
Megapixel camera arrays for high-resolution animal tracking in multiwell plates
Communications Biology 5:253

A McDermott‐Rouse, E Minga, I Barlow, L Feriani, PH Harlow, AJ Flemming, AEX Brown
Behavioral fingerprints predict insecticide and anthelmintic mode of action
Molecular Systems Biology 17:e10267

A Javer, L Ripoll-Sanchez, AEX Brown
Powerful and interpretable behavioural features for quantitative phenotyping of C. elegans
Phil Trans R Soc B 373:20170375