Publications — Behavioural Phenomics

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2024

M Koopman, L Güngördü, L Janssen, RI Seinstra, JE Richmond, N Okerlund, R Wardenaar, P Islam, W Hogewerf, AEX Brown, EM Jorgensen, EAA Nollen
Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43 toxicity
Cell Reports 43:114204

R Maroofian, P Sarraf, TJ O’Brien, M Kamel, A Cakar, N Elkhateeb, T Lau, SJ Patil, CJ Record, A Horga, M Essid, L Selim, H Benrhouma, T Ben Younes, G Zifarelli, AT Pagnamenta, P Bauer, M Khundadze, A Mirecki, SM Kamel, MA Elmonem, EG Karimiani, Y Jamshidi, AC Offiah, AM Rossor, I Ben Youssef-Turki, CA Hübner, P Munot, MM Reilly, AEX Brown, S Nagy, H Houlden
RTN2 deficiency results in an autosomal recessive distal motor neuropathy with lower limb spasticity
Brain 147:2334

TJ O’Brien, IL Barlow, L Feriani, AEX Brown
Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
eLife accepted

2023

L Pu, J Wang, Q Lu, L Nilsson, A Philbrook, A Pandey, L Zhao, R van Schendel, A Koh, TV Peres, WH Hashi, SL Myint, C Williams, JD Gilthorpe, SN Wai, A Brown, M Tijsterman, P Sengupta, J Henriksson, C Chen
Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans
Nature Communications 14:8410

F Catalano, TJ O’Brien, AA Mekhova, LV Sepe, M Elia, R De Cegli, I Gallotta, P Santonicola, G Zampi, EY Ilyechova, AA Romanov, PD Samuseva, J Salzano, R Petruzzelli, EV Polishchuk, A Indrieri, B Kim, AEX Brown, LV Puchkova, E Di Schiavi, RS Polishchuk
A new C. elegans model to study copper toxicity in Wilson disease
Traffic 25:e12920

K Saida, R Maroonfian, T Sengoku, T Mitani, A T Pagnamenta, D Marafi, MS Zaki, TJ O’Brien, [. . . 62 co-authors. . . ], AEX Brown, JG Gleeson, JR Lupski, H Houlden, N Matsumoto
A cohort of 38 cases with brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants
Genetics in Medicine 25:90

2022

E Rosenhahn*, TJ O’Brien*, MS Zaki, I Sorge, D Wieczorek, K Rostasy, A Vitobello, S Nambot, FS Alkuraya, MO Hashem, A Alhashem, B Tabarki, AS Alamri, AH Al Safar, DK Bubshait, NF Alahmady, JG Gleeson, MS Abdel-Hamid, N Lesko, S Ygberg, SP Correia, A Wredenberg, S Alavi, SM Seyedhassani, ME Nasab, H Hussien, TEI Omar, I Harzallah, R Touraine, H Tajsharghi, H Morsy, H Houlden, M Shahrooei, M Ghavideldarestani, GMH Abdel-Salam, A Torella, M Zanobio, G Terrone, N Brunetti-Pierri, A Omrani, J Hentschel, JR Lemke, H Sticht, RA Jamra, AEX Brown#, R Maroofian#, K Platzer#
Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications
American Journal of Human Genetics 109:1421
*contributed equally; #co-corresponding

I Barlow, L Feriani, E Minga, A McDermott-Rouse, T O’Brien, Z Liu, M Hofbauer, JR Stowers, EC Andersen, SS Ding, AEX Brown
Megapixel camera arrays for high-resolution animal tracking in multiwell plates
Communications Biology 5:253

2021

A McDermott‐Rouse, E Minga, I Barlow, L Feriani, PH Harlow, AJ Flemming, AEX Brown
Behavioral fingerprints predict insecticide and anthelmintic mode of action
Molecular Systems Biology 17:e10267

VE Martinez-Miguel, C Lujan, T Espie, D Martinez-Martinez, S Moore, C Backes, S Gonzalez, ER Galimov, AEX Brown, M Halic, K Tomita, C Rallis, T von der Haar, F Cabreiro, I Bjedov
Increased fidelity of protein synthesis extends lifespan
Cell Metabolism 33:2288

P Nambyiah, AEX Brown
Quantitative behavioural phenotyping to investigate anaesthesia induced neurobehavioural impairment
Scientific Reports 11:1

Y Sonobe, J Aburas, G Krishnan, AC Fleming, G Ghadge, P Islam, EC Warren, Y Gu, MW Kankel, AEX Brown, E Kiskinis, TF Gendron, F Gao, RP Roos, P Kratsios
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation
Nature Communications 12:6025

2020

D Hadjieconomou, G King, P Gaspar, A Mineo, L Blackie, T Ameku, C Studd, A Mendoza, F Diao, BH White, AEX Brown, P Plaçais, T Préat, I Miguel-Aliaga
Enteric neurons increase maternal food intake during reproduction
Nature 587:455

F Marques, S Thapliyal, A Javer, P Shrestha, AEX Brown, DA Glauser
Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions
PLOS Genetics 16:e1009102

Y Li, A Osuma, E Correa, MA Okebalama, P Dao, O Gaylord, J Aburas, P Islam, AEX Brown, P Kratsios
Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function
eLife 9:e59464

H Newton, YF Wang, L Camplese, JB Mokochinski, HB Kramer, AEX Brown, L Fets, S Hirabayashi
Systemic muscle wasting and coordinated tumour response drive tumourigenesis
Nature Communications 7:4653

SS Ding, LS Muhle, AEX Brown, LJ Schumacher, RG Endres
Comparison of solitary and collective foraging strategies of Caenorhabditis elegans in patchy food distributions
Phil Trans R Soc 375:20190382

CN Martineau, AEX Brown, P Laurent
Multidimensional phenotyping predicts lifespan and quantifies health in Caenorhabditis elegans
PLOS Computational Biology 16:e1008002

CL Essmann, D Martinez-Martinez, R Pryor, K Leung, KB Krishnan, PP Lui, NDE Greene, AEX Brown, VM Pawar, MA Srinivasan, F Cabreiro
Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans
Nature Communications 11:1

SS Ding, M Romenskyy, KS Sarkisyan, AEX Brown
Measuring Caenorhabditis elegans Spatial Foraging and Food Intake Using Bioluminescent Bacteria
Genetics 214:577

W Feng, Y Li, P Dao, J Aburas, P Islam, B Elbaz, A Kolarzyk, AEX Brown, P Kratsios
A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life
eLife 9: e50065

2019

SS Ding*, LJ Schumacher*, AE Javer, RG Endres, AEX Brown
Shared behavioral mechanisms underlie C. elegans aggregation and swarming
eLife 8:e43318
*contributed equally

2018

A Javer, M Currie, C Lee, J Hokanson, K Li, CN Martineau, E Yemini, LJ Grundy, C Li, Q Ch’ng, WR Schafer, EAA Nollen, R Kerr, AEX Brown
An open-source platform for analyzing and sharing worm-behavior data
Nature Methods 15:645

A Javer, L Ripoll-Sanchez, AEX Brown
Powerful and interpretable behavioural features for quantitative phenotyping of C. elegans
Phil Trans R Soc B 373:20170375
Special issue: [Intro] [Contents]

YL Chew, LJ Grundy, AEX Brown, I Beets, WR Schafer
Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in C. elegans via the receptor SEB-3
Phil Trans R Soc B 373:20170375
Special issue: [Intro] [Contents]

AEX Brown, BL de Bivort
Ethology as a physical science
Nature Physics 14:653

2013

E Yemini, T Jucikas, L Grundy, AEX Brown*, WR Schafer*
A database of C. elegans behavioral phenotypes
Nature Methods 10:877–879

AEX Brown, E Yemini, L Grundy, T Jucikas, WR Schafer
A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion
Proc. Nat. Acad. Sci. USA 110:791-796.
Coverage: [F1000 (rated exceptional)] [Nature Methods highlight]

2012

CA Russell, JM Fonville, AEX Brown, DF Burke, DL Smith, SL James, S Herfst, S van Boheemen, M Linster, EJ Schrauwen, L Katzelnick, A Mosterín, T Kuiken, E Maher, G Neumann, ADME Osterhaus, Y Kawaoka, RAM Fouchier, DJ Smith
The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host
Science 336:1541-1547.
Coverage: [Science News & Analysis] [New York Times]

F Rehfeldt, AEX Brown, M Raab, S Cai, AL Zajac, A Zemel, DE Discher
Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells
Integrative Biology 4:422-430

2011

AEX Brown, WR Schafer
Unrestrained worms bridled by the light
Nature Methods 8:129-30

A Zhmurov, AEX Brown, RI Litvinov, RI Dima, JW Weisel, V Barsegov
Mechanism of fibrin(ogen) forced unfolding
Structure 19:1615-24

PK Purohit, RI Litvinov, AEX Brown, DE Discher, JW Weisel
Protein unfolding accounts for the unusual mechanical behavior of fibrin networks
Acta Biomaterialia 7:2374-2383

2010

A Zemel*, F Rehfeldt*, AEX Brown, DE Discher, SA Safran
Optimal matrix rigidity for stress-fiber polarization in stem cells
Nature Physics 6:468-473 (2010)
*contributed equally

K Rajagopal, A Mahmud, DA Christian, JD Pajerowski, AEX Brown, SM Loverde, DE Discher
Curvature-Coupled Hydration of Semicrystalline Polymer Amphiphiles Yields flexible Worm Micelles but Favors Rigid Vesicles: Polycaprolactone-Based Block Copolymers
Macromolecules 43:9736–9746

CC Krieger, N Bhasin, M Tewari, AEX Brown, D Safer, HL Sweeney, DE Discher
Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: Mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics
Cytoskeleton 67:796-807

A Buxboim, K Rajagopal, AEX Brown, DE Discher
How deeply cells feel: methods for thin gels
Journal of Physics: Condensed Matter 22:194116

A Zemel, F Rehfeldt, AEX Brown, DE Discher, SA Safran
Cell shape, spreading symmetry and the polarization of stress-fibers in cells
Journal of Physics: Condensed Matter 22:194110

2009

AEX Brown and DE Discher
Conformational Changes in Cell and Matrix Physics
Current Biology 19:R781-R789

AEX Brown, RI Litvinov, DE Discher, PK Purohit, JW Weisel
Multiscale Mechanics of Fibrin Polymer: Gel Stretching with Protein Unfolding and Loss of Water
Science 325:741-744.
Coverage: [Eurekalert] [NPR]

AEX Brown*, A Hategan*, D Safer, YE Goldman, DE Discher
Cross-correlated TIRF/AFM reveals Asymmetry in Self-assembled Synthetic Myosin Filaments
Biophysical Journal 96:1952-1960.
*contributed equally

2008

M Kulic, AEX Brown, H Kim, C Kural, B Blehm, PR Selvin, PC Nelson, VI Gelfand
The Role of Microtubule Movement in Bidirectional Organelle Transport
Proc. Nat. Acad. Sci. 105:10011-10016.

2007

AEX Brown, RI Litvinov, DE Discher, JW Weisel
Forced Unfolding of Coiled-coils in Fibrinogen by Single Molecule AFM
Biophysical Journal - Letters. 92:L39-L41.

2004

A Brown, I Skanes, MR Morrow
Pressure Induced Ordering in mixed-lipid bilayers
Physical Review E 69:011913.